Inositol for PCOS: 6 Pointers and Possible Side Effects - Verywell Health In addition, the total duration over which a person has been using niacin might also dictate whether weight change occurs from regular administration. But thats not all. Item Number: 2636 Serving size: 1 softgel. Inositol Hexanicotinate (NIACIN) Review - Benefits, Side Effects & Uses Although it is possible that increasing niacin intake mightve played a role in causing obesity (along with other factors), its causative role cannot be proven. Considering that obese rats exhibit carnitine deficiencies and these deficiencies are implicated in perpetuation of obesity, increasing carnitine concentrations with niacin supplementation has therapeutic potential. While there is some evidence indicating that other adverse reactions such as hyperglycemia, insulin abnormalities, and/or hepatotoxicity may occur, these reactions arent automatically coupled with simultaneous weight change. Prescribed for Life Inositol HexaNicotinate (HexaNiacinate) Powder - No Molecular Weight: 810.73. (2014) investigated the effect of long-term niacin administration on insulin tolerance in mice over a 15-week duration. Find out how you need to take inositol, possible side effects of this substance, and how to decide which inositol supplement may be best for weight loss. Adequate niacin intake is necessary to prevent onset of a medical condition known as pellagra in which symptoms of diarrhea, dermatitis, and dementia occur. In addition to decreased appetite (from side effects) and/or consciously decreasing caloric intake (in fear of aggravating preexisting side effects) certain side effects may directly cause weight loss. One of the most widely studied of these is inositol hexaniacinate (IHN). Inositol for Weight Loss, Fat Burning & Liver Function - Fitness Edge Expedited niacin metabolism occurs as a result of upregulated activity in niacin-degrading enzymes. The mechanism by which blood sugar was increased involved GPR109A (G-protein coupled receptor 109A) activation within islet beta cells. If a drug is depleting 20 mg of niacin daily, and youre supplementing with 1000 mg niacin per day, this may modify your biological dose-response to niacin and ultimately affect weight change. Researchers believe that the reduced generation of reactive oxygen species likely contributed to the decreased inflammation. Research by Ukkola and Santaniemi (2002) suggests that adiponectin concentrations are inversely correlated with body fat percentage in adults. The oils, in particular, being some of the best oils for hair growth on the market. It is important to emphasize the fact that the dosage taken, as well as regularity of administration influence whether weight change occurs over a short or long-term of niacin supplementation. Rats fed a diet containing 0.5% nicotinamide excreted the metabolite Nicotinamide-N-oxide plus nicotinic acid and nicotinuric acid. Along with choline, it works like a pick axe does to dirt and rock. Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Also, Inositol has been studied as a therapeutic option for the treatment of gestational diabetes. The compound in its powder form has a whitish crystalline appearance and is soluble in both water and organic solvents. 6. On a scale of 1 to 10 (with 1 being least effective and 10 being highly effective), what rating would you assign to niacin as a weight loss supplement? Learn how your comment data is processed. When the cells cannot absorb glucose, levels of this sugar build up in the blood which will eventually lead to diabetes and obesity. Extreme supratherapeutic doses (such as 100-fold the recommended daily amount) is toxic to the body. Inositol, or more precisely myo-inositol, is a carbocyclic sugar that is found in many plants and animals. Fat synthesis & storage increase: Individuals who are overweight or obese generally accumulate excessive amounts of body fat. Though these findings were derived from rat studies and might not apply to humans, it is possible that similar epigenetic changes are induced by niacin supplementation in humans over a long-term. 2010: Chronic niacin overload may be involved in the increased prevalence of obesity in US children. It is hypothesized that overconsumption of niacin (vitamin B3) over a long-term may have lead to serum deficits. Inositol has lots of different health benefits. The powder is easily dissolved in water or juice. 2012: Effect of graded levels of niacin supplementation of a semipurified diet on energy and nitrogen balance, growth performance, diarrhea occurrence, and niacin metabolite excretion by growing swine. Myo-inositol Hexanicotinate. An earlier report by Sellbom and Gunstad (2012) suggests that obesity may induce cognitive dysfunction and modulate neural structure within the brain. Increase your energy levels to keep up with the kids or to run that 5K. If youre gaining weight while taking niacin and prednisone, the weight gain might be fully attributable to the prednisone. Studies in animal models (cattle, chickens, rats) show that supratherapeutic niacin intake leads to increased daily feed intake. Despite the fact that mega-dosing with niacin may induce a toxicity that causes weight loss, its unclear as to whether the toxicity is dangerous over the long-term based on the fact that mega-dosing with niacin to treat hypercholesterolemia seems safe and conducive to general health among those with the condition. Mostly, it may cause some stomach discomfort and loose stool when you are starting out with supplementation. A recent review suggests that inositol therapy can reduce insulin resistance, improve ovarian function, and reduce androgen levels in women with PCOS. Its always advised to seek medical advice before taking any supplement to ensure there are no serious, unknown, underlying conditions. Inositol Hexanicotinate Bulk Powder Supplier | NutriAvenue Related Substance: Complies to BP Standard. Ding, Li, and Wen (2015) conducted a meta-analysis to determine the effect of niacin supplementation on glucose of patients with type 2 diabetes. are a big contributing factor. Note: The author of this site is not engaged in rendering professional advice or services to the individual reader. Specifically, niacin supplementation activates PPARs (peroxisome proliferator-activated receptors) whereby gene expression is altered to enhance carnitine uptake (via OCTN2) and synthesis (via gamma-BBD and 4-N-TMABA-DH). The inositols and polycystic ovary syndrome. Acetone: < 0.5% . So why can people supplement with niacin or take drugs like Niaspan without experiencing weight gain? Some propose that chronic low-level inflammation associated with obesity might be to blame for cognitive decline. Note: Some drugs have been theorized to deplete niacin reserves. It is understood that niacin plays a role in the conversion of folate to tetrahydrofolate, which in turn is converted to tetrahydrobiopterin. One might surmise that lack of weight change (loss/gain) on Niaspan could be a result of a restricted dosage range (between 1000 mg to 3000 mg) associated with treating medical conditions. Life Extension No Flush Niacin contains a special form of niacin, inositol hexanicotinate, which allows you to take advantage of the benefits without the characteristic flush that many find bothersome. Inositol Hexanicotinate (IHN) 500 mg - Treat Depression and Obesity However, I suggest consulting a doctor just to be safe. Inositol: Benefits, Side Effects and Dosage - Healthline Through increasing serotonin levels, inositol lifts mood and even helps with mental health issues, such as depression, OCD and anxiety (4), (5), (6). Flush-Free Niacin Inositol Hexanicotinate helps support general blood vessel and circulatory function. Furthermore, cellular adaptation to osmotic stress is a vital process that protects cells from the effects of dehydration or edema. Researchers have found that some people with depression, anxiety, and compulsive disorders have lower levels of inositol in their brain. When considering the fact that niacins effect on the biology of an animal is not the same as its effect within humans, its important to avoid extrapolating any findings suggestive of weight gain in animals to human users. 1000 mg to 3000 mg) are less likely to affect body weight and/or might even induce weight loss. How can you confirm that you wouldnt have lost more weight without the niacin supplementation than you did while taking it? It's lipotropic qualities makes for an unavoidable confrontation for fat stores. After continuing the diets for 6 weeks, researchers administered either a vehicle or niacin treatment for 5 weeks. administration details, genetics, medical conditions, etc.). If your body is needing an intervention, inositol could be exactly what you need. The occurrence of niacin-induced insulin resistance was evidenced by an inability of insulin to counteract endogenous glucose secretion. In humans, it is known that poor niacin intake can lead to pellagra, and in some cases, low body weight. Inositol Improves Insulin Sensitivity. Inflammation reduction: Another way in which niacin supplementation could help some individuals lose weight is by decreasing inflammation. When paired with a healthy diet, Inositol may help accelerate the weight loss and fat mass reduction with a slight increase of percent lean mass. It is a compound related to B vitamins that help improve insulin sensitivity. Do you feel tired and sick? Most individuals that have been taking niacin for an extremely short-term are unlikely to notice any weight change because they havent been using it long enough for biological changes to occur. Does Viibryd Cause Weight Loss or Gain? You can get your inositol-fix from a great variety of foods. If you happen to be in the unlucky subset of individuals who experiences a substantial appetite surge from niacin supplementation, youre probably going to gain weight. Country: USA Phone: +1-626 964-6910 Telefax: +1-626 964-6739 INQUIRY | ORDER Niacin is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts . 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