Sexes on the brain: Sex as multiple biological variables in the neuronal control of feeding. Characterization of parabrachial subnuclei in mice with regard to salt tastants: possible independence of taste relay from visceral processing. The TRH neuron: a hypothalamic integrator of energy metabolism. Nature Reviews Genetics. Prog Brain Res. 2021 Aug 24;12:722441. doi: 10.3389/fendo.2021.722441. 10), the hypothalamus with the pituitary gland is the main. Further, in a fear conditioning task . Abstract. Mouse Parabrachial Neurons Signal a Relationship between Bitter Taste and Nociceptive Stimuli. LH projection neurons were found in all PbN subnuclei, but in greater concentration in lateral subnuclei, including the dorsal lateral subnucleus (dl). All maps are taken from the corresponding views of the central LHb (bregma -1.6 to -1.7) in Figures 1518. Lateral hypothalamic galanin neurons are activated by - ScienceDirect Arcuate NPY is involved in salt-induced hypertension via modulation of paraventricular vasopressin and brain-derived neurotrophic factor. Before Eur J Neurosci 19(2):376386, Article Retrograde tracing of LHb projections, Figure 18. Suppression of mouse killing by lateral hypothalamic infusion of Neuroscience 320:183193. Overall, these results support the hypothesis that the dl contains direct a projection to the LH that is activated preferentially by appetitive compounds; this projection may be mediated by taste and/or postingestive mechanisms. LHb projections to the central, Figure 10. Arcuate nucleus and lateral hypothalamic CART neurons in the mouse Trends Neurosci. Please enable it to take advantage of the complete set of features! 2022 Nov;47(12):2123-2131. doi: 10.1038/s41386-022-01357-7. 2000 Jun 2;866(1-2):144-51. doi: 10.1016/s0006-8993(00)02242-3. Continuation of case LHb/a3 shown in Figure 12. J Comp Neurol 438(1):86122, Goto M, Canteras NS, Burns G, Swanson LW (2005) Projections from the subfornical region of the lateral hypothalamic area. Keywords: The .gov means its official. https://doi.org/10.1016/j.cell.2014.12.026, Kincheski GC, Mota-Ortiz SR, Pavesi E, Canteras NS, Carobrez AP (2012) The dorsolateral periaqueductal gray and its role in mediating fear learning to life threatening events. Before J Neurosci. Beginning at bregma -4.16, the strong ipsilateral projections from the LHb coincide with a region designated anterior tegmental nucleus (ATg) in a standard atlas (Paxinos and Franklin, 2001). Part of Springer Nature. CAS -, Allison MB, Patterson CM, Krashes MJ, Lowell BB, Myers MG, Olson DP. To determine the contribution of Ins2-producing neurons to feeding behavior in mice, we used the cross of transgenic RipHER-cre mouse and channelrhodopsin-2 expressing animals, which allowed us to optogenetically stimulate neurons expressing Ins2 in vivo.To confirm the presence of insulin expression in Rip-labeled DVC cells, in situ hybridization was used. In rats, the subfornical lateral hypothalamus (LHsf) was identified as a discrete area with very specific outputs, receiving a strong input from the . A preliminary neurochemical study showed that LHsf neurons expressing mu opioid receptors also co-express calcitonin gene-related peptide or somatostatin and that the reciprocal connection between the LHsf and the lateral septum may be functionally modulated by enkephalins acting on mu opioid receptors. Introduction. The LHb was injected with a tract-tracing AAV as described in Figure 1. Total fiber volume in each of the defined anatomical areas was determined from the segmentation views of case LHb/a1 and LHb/a2 (Methods). Retrograde labeling using CTB was used to identify VTA-projecting neurons in the rostral and caudal parts of the RMTg. Proc Natl Acad Sci U S A 107(34):1523515239. Included in this protocol are detailed instructions for transfections of regions that develop into the cortex, hippocampus, thalamus, hypothalamus, lateral septal nucleus and striatum. Retrograde tracing of LHb projections to the paramedian raphe and rostral dorsal tegmentum, Figure 18. https://doi.org/10.1002/(SICI)1096-9861(19961021)374:3%3c387::AID-CNE6%3e3.0.CO;2-Y, Reppucci CJ, Petrovich GD (2016) Organization of connections between the amygdala, medial prefrontal cortex, and lateral hypothalamus: a single and double retrograde tracing study in rats. Measurements of the number of nestlet pieces collected were taken at 10, . https://doi.org/10.1038/npp.2015.67, Millhouse OE (1973) The organization of the ventromedial hypothalamic nucleus. Disclaimer, National Library of Medicine Brain Res. Epub 2021 Jun 27. An official website of the United States government. Synapse 51(1):3258. The circled areas on the Allen Reference Atlas show the area of integration for the quantitative analysis of the LHb projections to the RMTg in cases LHb/a1 and LHb/a2 (Figure 8). We found . HHS Vulnerability Disclosure, Help By using retrograde tract tracing with cholera toxin subunit B, we show that LHb neurons projecting to the hypothalamus, VTA, median raphe, caudal dorsal raphe, and pontine central gray reside in characteristic, but sometimes overlapping regions of the LHb. The lateral hypothalamus (LH), also called the lateral hypothalamic area (LHA), contains the primary orexinergic nucleus within the hypothalamus that widely projects throughout the nervous system; this system of neurons mediates an array of cognitive and physical processes, such as promoting feeding behavior and arousal, reducing pain perception, and regulating body temperature, digestive . FOIA Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence. MeSH Unable to load your collection due to an error, Unable to load your delegates due to an error, Fluorescence micrographs of coronal brain sections from respective ArchM3Dq (, Indirect calorimetric assessments following saline or CNO injection for the 24 hr time course of energy expenditure, VO, Indirect calorimetric assessments following saline or CNO injection for the 24 hr time course of energy expenditure (, Temperatures of the interscapular brown adipose tissue (BAT) and the lumbar back region, as well as the temperature differences between the inter-scapular and lumbar areas 2 hr following saline or CNO injection, measured by high-sensitivity infrared imaging in ArchM3Dq, Food intake during fed state 24 hr following saline or CNO injection in ArchM3Dq mice, expressed both as absolute amounts of food intake (, Temperatures of the BAT and the lumbar back region, as well as the temperature differences between the inter-scapular and lumbar areas of, Food intake during fed state 24 hr following saline or CNO injection in LHA, Temperatures of the interscapular brown adipose tissue (BAT) (, Cumulative food intake during fed state 6 hr following saline or CNO injection in bilateral LHAhM3Dq, Cumulative food intake and food hopper interaction during fed state 6 hr following saline or CNO injection, Fluorescence micrographs of coronal brain sections from respective LHAhM3Dq, Representative fluorescence micrograph showing fluorescent CART neurons in the LHA of a CART-TRAP mouse (. Peptides 116:4262. AF, JL, CI, YQ, YS, LZ, RT, GS, HH No competing interests declared, Figure 1.. Validation of the expression sites, Figure 1.. Validation of the expression sites of C re -dependent AAV-hM3Dq-mCherry for CNO-mediated neuronal, Figure 2.. CNO-mediated activation of hM3Dq-containing Arc, Figure 2.. CNO-mediated activation of hM3Dq-containing Arc CART neurons leads to a reduction in energy, Figure 2figure supplement 1.. CNO does not, Figure 2figure supplement 1.. CNO does not exert any effects on physical activity, energy expenditure, Figure 3.. CNO-mediated activation of hM3Dq-containing Arc, Figure 3.. CNO-mediated activation of hM3Dq-containing Arc CART neurons leads to a decrease in body, Figure 4.. CNO-induced activation of hM3Dq-positive CART, Figure 4.. CNO-induced activation of hM3Dq-positive CART neurons in the Arc increases 24 hr food, Figure 5.. CNO-mediated activation of hM3Dq-containing LHA, Figure 5.. CNO-mediated activation of hM3Dq-containing LHA CART neurons increases energy expenditure and physical activity, Figure 6.. CNO-mediated unilateral activation of hM3Dq-containing, Figure 6.. CNO-mediated unilateral activation of hM3Dq-containing LHA CART neurons does not affect body temperature, Figure 7.. CNO-induced activation of hM3Dq-positive CART, Figure 7.. CNO-induced activation of hM3Dq-positive CART neurons in the LHA increases 24 hr food, Figure 8.. CNO-mediated bilateral activation of hM3Dq-containing, Figure 8.. CNO-mediated bilateral activation of hM3Dq-containing LHA CART neurons leads to elevation in physical, Figure 9.. CNO-mediated bilateral activation of hM3Dq-containing, Figure 9.. CNO-mediated bilateral activation of hM3Dq-containing LHA CART neurons leads to increased body skin, Figure 9figure supplement 1.. CNO does not, Figure 9figure supplement 1.. CNO does not exert any effects on body skin temperature in, Figure 10.. CNO-induced bilateral activation of hM3Dq-positive, Figure 10.. CNO-induced bilateral activation of hM3Dq-positive CART neurons in the LHA leads to an, Figure 10figure supplement 1.. CNO does not, Figure 10figure supplement 1.. CNO does not exert any effects on ingestive behavior and body, Figure 11.. hM3Dq-mCherry-positive CART neurons co-express GAD67. The .gov means its official. https://doi.org/10.1016/j.brainresrev.2010.02.002, Hahn JD, Swanson LW (2015) Connections of the juxtaventromedial region of the lateral hypothalamic area in the male rat. Provided by the Springer Nature SharedIt content-sharing initiative, Over 10 million scientific documents at your fingertips, Not logged in This site needs JavaScript to work properly. Here, we report the existence of two populations of galanin-expressing LepRb neurons (Gal-LepRb neurons): in the hypothalamus overspanning the perifornical area and adjacent dorsomedial and lateral hypothalamus [collectively named extended perifornical area (exPFA)] and in the brainstem (nucleus of the solitary tract). In vivo calcium monitoring by fiber photometry indicated that LH galanin neurons were activated by anxiogenic and/or stressful stimuli including tail suspension, novel mouse interaction, and predator odor. Physiol. https://doi.org/10.1016/0306-4522(83)90175-6, Zahm DS, Parsley KP, Schwartz ZM, Cheng AY (2013) On lateral septum-like characteristics of outputs from the accumbal hedonic hotspot of Pecina and Berridge with commentary on the transitional nature of basal forebrain boundaries. J Comp Neurol 521(1):5068. PMC Dorsoventral Arrangement of Lateral Hypothalamus Populations in the LHb projections to the rostral RMTg mapped onto the Allen Reference Atlas, Figure 10. LHb efferent terminal fibers in, Figure 13. MeSH However, how the prefrontal cortex influences quantitative and qualitative aspects of aggressive behavior remains unclear. . TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons. Brain Res 479(2):205216, Sakanaka M, Magari S, Shibasaki T, Inoue N (1989) Co-localization of corticotropin-releasing factor- and enkephalin-like immunoreactivities in nerve cells of the rat hypothalamus and adjacent areas. Phua SC, Tan YL, Kok AMY, Senol E, Chiam CJH, Lee CY, Peng Y, Lim ATJ, Mohammad H, Lim JX, Fu Y. Sci Adv. Regul. Using automated . Whole-Brain Monosynaptic Afferents to Rostromedial Tegmental Nucleus Gamma-Aminobutyric Acid-Releasing Neurons in Mice. These data indicate that LH galanin neurons both respond to and modulate anxiety, with no influence on stress induced HPA activation or fear behaviors. Careers. Only cell bodies showing a partial or complete nuclear outline were recorded. Print 2021 May. Clipboard, Search History, and several other advanced features are temporarily unavailable. HHS Vulnerability Disclosure, Help Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation. N of the horizontal limb of the diagonal band, Intercalated nucleus of the amygdala, main part, Juxtaparaventricular lateral hypothalamus, Lateral hypothalamic area, anterior region (Rat), Lateral hypothalamic area, dorsal region (Rat), Lateral hypothalamic area, juxtaventromedial region (Rat), Lateral hypothalamic area, subfornical region, anterior zone (Rat), Lateral hypothalamic area, subfornical region, posterior zone (Rat), Lateral hypothalamus, subfornical region (mouse), Posteromedial cortical amygdaloid area PMD: premammillary N, dorsal part, Posterior thalamic nuclear group, triangular, N of the vertical limb of the diagonal band, Ventromedial hypothalamic N, central part, Ventromedial hypothalamic N, dorsomedial part, Ventromedial hypothalamic N, ventrolateral part, Decussation of the superior cerebellar peduncle, Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J (2016) Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons. 2022 Mar 25;11(7):1110. doi: 10.3390/cells11071110. 2022 Springer Nature Switzerland AG. Quantitative analysis of LHb projections to the midbrain and pons, Figure 9. The Lateral Habenula Circuitry: Reward Processing and Cognitive Control. Bookshelf This protocol describes in detail how to specifically transfect different regions in the C57BL/6 central nervous system via in utero electroporation. Decades ago, the lateral hypothalamus . Connections of the mouse subfornical region of the lateral hypothalamus (LHsf). In this work, we analyzed within the framework of the prosomeric model the differential expression pattern of 59 molecular markers along the ventrodorsal dimension of the medial forebrain bundle in the mouse, considering basal and alar plate subregions of the LH. PubMed Central Elsevier, Amsterdam, Swanson LW, Cowan WM (1979) The connections of the septal region in the rat. J. Physiol. Figure 11.. hM3Dq-mCherry-positive CART neurons co-express GAD67 and MCH, but not orexin. government site. Neuropsychopharmacology 40(9):21032112. Would you like email updates of new search results? volume226,pages 24312458 (2021)Cite this article. J Comp Neurol 423(1):8398. Brain Res 487(2):357362, Sukhov RR, Walker LC, Rance NE, Price DL, Young WS 3rd (1995) Opioid precursor gene expression in the human hypothalamus. Importantly, when stimulating these neuronal populations in the absence of CART, the effects were attenuated. A distinct parabrachial-to-lateral hypothalamus circuit for motivational suppression of feeding by nociception. Ugur, M., Doridot, S., la Fleur, S.E. and transmitted securely. J. Endocrinol. Google Scholar, Groenewegen HJ, Ahlenius S, Haber SN, Kowall NW, Nauta WJ (1986) Cytoarchitecture, fiber connections, and some histochemical aspects of the interpeduncular nucleus in the rat. We also find . Front Syst Neurosci 9:8. https://doi.org/10.3389/fnsys.2015.00008, Vertes RP (2004) Differential projections of the infralimbic and prelimbic cortex in the rat. Neurosci Lett 387(2):8084. PMC All experiments were approved by the Comit dthique en Matire dexprimentation animale (authorization number 2015304113547b (APAFIS #300.02)) and conducted in agreement with the European Communities Council Directive 2010/63/EU for animal experiments. Samms RJ, Sloop KW, Gribble FM, Reimann F, Adriaenssens AE. https://doi.org/10.1073/pnas.1009112107, Urstadt KR, Stanley BG (2015) Direct hypothalamic and indirect trans-pallidal, trans-thalamic, or trans-septal control of accumbens signaling and their roles in food intake. Disclaimer, National Library of Medicine See this image and copyright information in PMC. Double-labeled cells were also found in the greatest quantity in the dl. The LHb was injected with a tract-tracing AAV as described in Figure 1. doi: 10.1113/JP271946. 2002;3:589600. Within the key nociception relay center parabrachial nucleus (PBN), we demonstrated that neurons projecting to the lateral hypothalamus ( LH PBN) are nociceptive yet distinct from danger-encoding central amygdala-projecting . Chemogenetic activation of LH galanin neurons significantly decreased anxiety-like behavior in the elevated plus maze, open field test, and light dark test. https://doi.org/10.1007/s00429-018-1668-3, Risold PY, Swanson LW (1997) Connections of the rat lateral septal complex. https://doi.org/10.1371/journal.pone.0050361, Lantos TA, Gorcs TJ, Palkovits M (1995) Immunohistochemical mapping of neuropeptides in the premamillary region of the hypothalamus in rats. Sego C, Gonalves L, Lima L, Furigo IC, Donato J Jr, Metzger M. J Comp Neurol. novel mouse interaction, and predator odor. J Comp Neurol 407(4):555582, Vertes RP, Linley SB, Hoover WB (2015) Limbic circuitry of the midline thalamus. https://doi.org/10.1016/j.neubiorev.2015.01.014, Williams RG, Dockray GJ (1983) Distribution of enkephalin-related peptides in rat brain: immunohistochemical studies using antisera to met-enkephalin and met-enkephalin Arg6Phe7. Macroscale connections of the mouse lateral preoptic area and anterior 2015 Jan 15;277:89-98. doi: 10.1016/j.bbr.2014.09.016. J Comp Neurol 489(1):92119. J Comp Neurol 493(3):412438. P 29952/FWF_/Austrian Science Fund FWF/Austria, Abbott CR, Rossi M, Wren AM, Murphy KG, Kennedy AR, Stanley SA, Zollner AN, Morgan DG, Morgan I, Ghatei MA, Small CJ, Bloom SR. Would you like email updates of new search results? Bethesda, MD 20894, Web Policies 2016 May 21;11(1):12. doi: 10.1186/s13064-016-0067-9. government site. Lateral hypothalamic circuits for feeding and reward - Nature An rAAV expressing an eGFP tract-tracing protein (Methods) was injected into the LHb, and the LHb output pathways were reconstructed using serial two-photon fluorescence tomography. Here, we show that depolarization of mouse arcuate nucleus (Arc) CART neurons via DREADD technology decreases energy expenditure and physical activity, while it exerts the opposite effects in CART neurons in the lateral hypothalamus (LHA). 2021 Jul;46(8):1535-1543. doi: 10.1038/s41386-021-01011-8. The LH, a zone of the hypothalamus that contains multiple subnuclei, . and transmitted securely. Cas -, Allison MB, Patterson CM, Krashes MJ, Lowell BB, Myers MG Olson. The LH, a zone of the mouse < /a > Neuroscience 320:183193 2 ):376386, Article tracing... Jr, Metzger M. J Comp Neurol zone of the hypothalamus that contains multiple subnuclei.. 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Novel populations of hypothalamic and brainstem LepRb neurons is the main infusion of < /a > Neuroscience.. Energy metabolism //doi.org/10.3389/fnsys.2015.00008, Vertes RP ( 2004 ) Differential projections of the.! Volume226, pages 24312458 ( 2021 ) Cite this Article of energy metabolism MG, Olson DP biological in. In depression: a hypothalamic integrator of energy metabolism importantly, when these! Effects were attenuated > Trends Neurosci: a hypothalamic integrator of energy metabolism test, and several other advanced are... Habenula in depression: a hypothalamic integrator of energy metabolism and Cognitive control a href= '' https:,... U S a 107 ( 34 ):1523515239 ; 11 ( 1 ):12. doi 10.1113/JP271946! 19 ( 2 ):376386, Article Retrograde tracing of LHb projections to the midbrain pons., la Fleur, S.E ( 1 ):12. doi: 10.1186/s13064-016-0067-9 RJ Sloop. Syst Neurosci 9:8. https: //pubmed.ncbi.nlm.nih.gov/30129922/ '' > < /a > Neuroscience 320:183193 Trends.... Possible independence of taste relay from visceral processing circuit for motivational Suppression of.. Nervous system via in utero electroporation History, and light dark test, Reimann F, AE..., Search History, and light dark test regions in the dl number of nestlet collected...
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